Journal: Cold Spring Harbor Molecular Case Studies

Article Title: Expanding the phenotypic spectrum in RDH12-associated retinal disease

doi: 10.1101/mcs.a004754

Figure Lengend Snippet: Clinical phenotypes of RDH12-associated patients. Widefield fundus photography, fundus autofluorescence imaging, and optical coherence tomography to demonstrate degree of retinal dystrophy in patients. ( A – C ) OGI519-1068, age 14; ( D – F ) OGI3079-4672, age 33; ( G – I ) OGI3076-4666, age 14; ( J – L ) OGI2356-3915, age 11; ( M – O ) OGI1242-2406, age 31; ( P – R ) OGI3077-4669, age 29.

Article Snippet: Retinal structure was assessed with fundus photography (Topcon Medical Systems; Optos), spectral-domain optical coherence tomography (SD-OCT: Spectralis, Heidelberg Engineering; Cirrus, Carl Zeiss), and fundus autofluorescence (FAF; Spectralis, Heidelberg Engineering; Optos).

Techniques: Imaging, Tomography

Journal: Journal of Ophthalmology

Article Title: The Fundus Autofluorescence Spectrum of Punctate Inner Choroidopathy

doi: 10.1155/2015/202097

Figure Lengend Snippet: FAF and corresponding SD-OCT, FA, and ICGA findings of punctate inner choroidopathy.

Article Snippet: Additionally, best corrected visual acuity measurement using Snellen charts, slit-lamp examinations, dilated fundoscopy, fundus photography (Carl Zeiss, Inc., Jena, Germany, or Topcon Corp., Tokyo, Japan), fluorescein angiography (FA) (Spectralis HRA, Heidelberg Engineering, Heidelberg, Germany), and SD-OCT (Spectralis SD-OCT, Heidelberg Engineering, Heidelberg, Germany, or Cirrus HD-OCT5000, Carl Zeiss Meditec, Inc., Dublin, CA) were conducted.

Techniques:

Journal: Journal of Ophthalmology

Article Title: The Fundus Autofluorescence Spectrum of Punctate Inner Choroidopathy

doi: 10.1155/2015/202097

Figure Lengend Snippet: The presence of hypoautofluorescent spot with hyperautofluorescent margin on FAF imaging (e, f, g, and h) and corresponding findings on fundus photography (a, b) and SD-OCT (c, d). (a) A yellow-white creamy spot was shown on fundus photography. (c) SD-OCT revealed a hump-shaped chorioretinal nodule of moderate reflectivity breaking through RPE and Bruch's membrane (BM), beneath the OPL. Hyperautofluorescent margin was detected with SW-FAF imaging (e), while it was not obvious on NIR-FAF (g). Six weeks later, (b) the spot became larger on fundus photography. (d) On SD-OCT, the nodule regressed from the apex toward the choroidal part. (f) The hyperautofluorescent margin on SW-FAF disappeared. (h) The hypoautofluorescent spot on NIR-FAF enlarged.

Article Snippet: Additionally, best corrected visual acuity measurement using Snellen charts, slit-lamp examinations, dilated fundoscopy, fundus photography (Carl Zeiss, Inc., Jena, Germany, or Topcon Corp., Tokyo, Japan), fluorescein angiography (FA) (Spectralis HRA, Heidelberg Engineering, Heidelberg, Germany), and SD-OCT (Spectralis SD-OCT, Heidelberg Engineering, Heidelberg, Germany, or Cirrus HD-OCT5000, Carl Zeiss Meditec, Inc., Dublin, CA) were conducted.

Techniques: Imaging

Journal: Journal of Ophthalmology

Article Title: The Fundus Autofluorescence Spectrum of Punctate Inner Choroidopathy

doi: 10.1155/2015/202097

Figure Lengend Snippet: The presence of hypoautofluorescent spot without hyperautofluorescent margin on FAF (e, f, g, and h) and corresponding findings on fundus photography (a, b) and SD-OCT (c, d). (a) A spot with slight discoloration presented on fundus photography. (b) A sub-RPE nodule was shown on SD-OCT, penetrating BM to lift the RPE. A hypoautofluorescent lesionwasmore distinctively shown on NIR-FAF (g) compared to SW-FAF (e). (b) Eleven weeks later, the spot became larger on fundus photography. (d) The chorioretinal nodule on SD-OCT broke through RPE and BM, reaching the OPL. (f) The hypoautofluorescent spot on SW-FAF became more distinctive, with hyperautofluorescent margin around. (h) The hypoautofluorescent spot on NIR-FAF became darker.

Article Snippet: Additionally, best corrected visual acuity measurement using Snellen charts, slit-lamp examinations, dilated fundoscopy, fundus photography (Carl Zeiss, Inc., Jena, Germany, or Topcon Corp., Tokyo, Japan), fluorescein angiography (FA) (Spectralis HRA, Heidelberg Engineering, Heidelberg, Germany), and SD-OCT (Spectralis SD-OCT, Heidelberg Engineering, Heidelberg, Germany, or Cirrus HD-OCT5000, Carl Zeiss Meditec, Inc., Dublin, CA) were conducted.

Techniques:

Journal: Journal of Ophthalmology

Article Title: The Fundus Autofluorescence Spectrum of Punctate Inner Choroidopathy

doi: 10.1155/2015/202097

Figure Lengend Snippet: Fundus photography (a, f), SW-FAF (b, g), FA (c, h), ICGA (d, i), and SD-OCT (e, j) of the right eye of a 24-year-old female at the initial visit and 5 weeks later. At the initial visit, her BCVA was 0.2. (a) There were scattered yellowish spots in the upper posterior pole in addition to the yellow-gray PIC lesions. (b) Diffuse hyperautofluorescent areas were shown on SW-FAF, which tended to emerge in the macula and around the optic disc. Additionally, the hypoautofluorescent PIC lesions were surrounded by hyperautofluorescent edge. (c) FA revealed patches of hyperfluorescence, which was especially obvious in late phase and the extent was smaller than it was on SW-FAF and ICGA.The PIC lesions showed hyperfluorescent spots with slight leakage. (d) Hypocyanescent spots were indicated in the late phase of ICGA. (e) The red line (crossing a PIC lesion and hyperautofluorescent areas on SW-FAF) shown on SD-OCT was dome-shaped high reflective materials (arrow), with underlying disrupted EZ. Additionally, an active lesion (stage III) was detected. Five weeks later, the MEWDS lesions faded completely on fundus photography (f), SW-FAF (g), FA (h), and ICGA (i). Meanwhile, the dome-shaped high reflective materials on SDOCT disappeared and disruption of EZ near-completely recovered (j). The hyperautofluorescent margin of the PIC lesion faded on SW-FAF (g). The PIC lesion regressed on SD-OCT (j). Her BCVA was improved to 0.32.

Article Snippet: Additionally, best corrected visual acuity measurement using Snellen charts, slit-lamp examinations, dilated fundoscopy, fundus photography (Carl Zeiss, Inc., Jena, Germany, or Topcon Corp., Tokyo, Japan), fluorescein angiography (FA) (Spectralis HRA, Heidelberg Engineering, Heidelberg, Germany), and SD-OCT (Spectralis SD-OCT, Heidelberg Engineering, Heidelberg, Germany, or Cirrus HD-OCT5000, Carl Zeiss Meditec, Inc., Dublin, CA) were conducted.

Techniques:

Journal: Journal of Ophthalmology

Article Title: The Fundus Autofluorescence Spectrum of Punctate Inner Choroidopathy

doi: 10.1155/2015/202097

Figure Lengend Snippet: Fundus photography (a, e), SW-FAF (b, f), ICGA (c), perimetry (d), and SD-OCT (g, h, i, and j) of the right eye of a 32-year-old female at the initial visit and 2 months later. The presented BCVA was 0.6. (a) Except for the atrophic lesions of PIC, nothing abnormal was shown on fundus photography. (b) Diffuse hyperautofluorescent patches were detected on SW-FAF, in addition to the hypoautofluorescence of atrophic PIC lesions. (c) Late phase of ICGA was normal in related areas except for some hypocyanescent spots nasal to the optic disc. (d) The visual field examination indicated blind spot enlargement and widespread visual field defects. With relative preservation at the fovea (i), SD-OCT imaging revealed diffuse loss of EZ in the peripapillary zone and in areas that corresponded with the enlarged blind spot. The ONL was preserved (g). Two months later, (e) no obvious change was observed on fundus photography. (f) The intensity of hyperautofluorescence on SW-FAF diminished. (h, j) The EZ reconstructed with focal disruption remained on SD-OCT.

Article Snippet: Additionally, best corrected visual acuity measurement using Snellen charts, slit-lamp examinations, dilated fundoscopy, fundus photography (Carl Zeiss, Inc., Jena, Germany, or Topcon Corp., Tokyo, Japan), fluorescein angiography (FA) (Spectralis HRA, Heidelberg Engineering, Heidelberg, Germany), and SD-OCT (Spectralis SD-OCT, Heidelberg Engineering, Heidelberg, Germany, or Cirrus HD-OCT5000, Carl Zeiss Meditec, Inc., Dublin, CA) were conducted.

Techniques: Preserving, Imaging